SCHEMBL14964015

SCHEMBL14964015

Cc1cc2c(-c3cccs3)c3sc(C)cc3c(-c3ccccc3)c2s1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 1/20 0.39
KDM4E B2RXH2 5/20 0.38
MEN1 O00255 4/20 0.38
KMT2A Q03164 4/20 0.38
ALDH1A1 P00352 3/20 0.38
MAPT P10636 3/20 0.35
ALOX5 P09917 1/20 0.35
HPGD P15428 2/20 0.35
NPSR1 Q6W5P4 1/20 0.35
CDK8 P49336 1/20 0.35
PRMT6 Q96LA8 1/20 0.34
CYP3A4 P08684 2/20 0.33
CYP2C9 P11712 2/20 0.33
ADK P55263 1/20 0.33
CYP2E1 P05181 1/20 0.33
CYP2A6 P11509 1/20 0.33
CYP2B6 P20813 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP2C19 P33261 1/20 0.33
PPARG P37231 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15277878 0.91 ACHE (0.38) ACHEKDM4EMEN1KMT2AALDH1A1
SCHEMBL14964002 0.85 CHEK1 (0.38) ACHEKDM4EALDH1A1MAPTHPGD
SCHEMBL15281525 0.83 ALDH1A1 (0.36) ACHEKDM4EMEN1KMT2AALDH1A1
SCHEMBL15279574 0.83 ADORA1 (0.35) ACHEKDM4EMEN1KMT2AALDH1A1
SCHEMBL15279573 0.81 DPP4 (0.43) KDM4EMEN1KMT2AALDH1A1MAPT
SCHEMBL19097325 0.77 ALDH1A1 (0.37) ACHEKDM4EMEN1KMT2AALDH1A1
SCHEMBL14964006 0.76 MAP3K8 (0.36) KDM4EALDH1A1MAPTHPGDNPC1
SCHEMBL14964010 0.74 MAP3K8 (0.35) KDM4EALDH1A1MAPTHPGDCYP3A4
SCHEMBL14964020 0.72 GSTP1 (0.42) ACHEMAPTCYP3A4CYP2C9CYP1A2
SCHEMBL1102369 0.72 NPC1 (0.35) KDM4EMEN1KMT2AALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9394406-B2 Polymers containing substituted benzodithiophene units, blends comprising these polymers, and devices comprising these polymers or blends MERCK PATENT GMBH (DE) 2016-07-19 US disclosed
US-20130126855-A1 POLYMERS CONTAINING SUBSTITUTED BENZODITHIOPHENE UNITS, BLENDS COMPRISING THESE POLYMERS, AND DEVICES COMPRISING THESE POLYMERS OR BLENDS MERCK PATENT GMBH (DE) 2013-05-23 US disclosed