SCHEMBL14964172

SCHEMBL14964172

N=C(c1nonc1Cn1nnc(N)n1)N(O)c1ccc(F)c(Br)c1

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 19/20 0.33
IDO2 Q6ZQW0 3/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16581795 0.84 IDO1 (0.34) IDO1IDO2
SCHEMBL14462387 0.82 IDO1 (0.36) IDO1IDO2
SCHEMBL14964343 0.81 IDO1 (0.35) IDO1
SCHEMBL14964191 0.81 IDO1 (0.40) IDO1
SCHEMBL14964277 0.80 IDO1 (0.32) IDO1
SCHEMBL14964324 0.79 IDO1 (0.36) IDO1IDO2
SCHEMBL5631534 0.77 IDO1 (0.39) IDO1IDO2
SCHEMBL5631538 0.77 IDO1 (0.39) IDO1IDO2
SCHEMBL16321669 0.77 IDO1 (0.50) IDO1
SCHEMBL5631546 0.76 IDO1 (0.61) IDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8450351-B2 N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase INCYTE CORPORATION (US) 2013-05-28 US claimed