Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 5/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14964216 | 1.00 | MAPT (0.37) | MAPTHTTALDH1A1TSHRIDO1 | |
| Trifluoroacetic Acid SCHEMBL15093562 | 0.95 | MAPT (0.37) | MAPTHTTALDH1A1TSHRIDO1 | |
| SCHEMBL14964209 | 0.90 | IDO1 (0.33) | IDO1 | |
| SCHEMBL14964211 | 0.90 | IDO1 (0.33) | IDO1 | |
| SCHEMBL16435132 | 0.90 | MCHR1 (0.33) | IDO1 | |
| SCHEMBL14964323 | 0.89 | IDO1 (0.32) | IDO1 | |
| SCHEMBL4972930 | 0.88 | IDO1 (0.31) | IDO1 | |
| SCHEMBL14964264 | 0.88 | MAPK1 (0.30) | MAPTHTT | |
| SCHEMBL14964262 | 0.88 | MAPK1 (0.30) | MAPTHTT | |
| SCHEMBL15093564 | 0.87 | ALDH1A1 (0.36) | MAPTHTTALDH1A1TSHRIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450351-B2 | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase | INCYTE CORPORATION (US) | 2013-05-28 | — | — | US | claimed |