Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 11/20 | 0.54 |
| ▸ | CDK2 | P24941 | 15/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 13/20 | 0.49 |
| ▸ | CCNA1 | P78396 | 11/20 | 0.49 |
| ▸ | CDK9 | P50750 | 8/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 7/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 12/20 | 0.47 |
| ▸ | CDK5R1 | Q15078 | 11/20 | 0.47 |
| ▸ | CSNK1A1 | P48729 | 6/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 5/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.47 |
| ▸ | CDK7 | P50613 | 4/20 | 0.47 |
| ▸ | CCNH | P51946 | 4/20 | 0.47 |
| ▸ | CCNK | O75909 | 4/20 | 0.47 |
| ▸ | CDK12 | Q9NYV4 | 4/20 | 0.47 |
| ▸ | CDK4 | P11802 | 3/20 | 0.47 |
| ▸ | CCND1 | P24385 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14964230 | 0.87 | CDK2 (0.59) | DYRK1ACDK2CCNA2CCNA1CDK9 | |
| SCHEMBL14977879 | 0.82 | DYRK1A (0.79) | DYRK1ACDK2CCNA2CCNA1CDK9 | |
| SCHEMBL14964243 | 0.82 | DYRK1A (0.79) | DYRK1ACDK2CCNA2CCNA1CDK9 | |
| SCHEMBL14964241 | 0.82 | DYRK1A (0.79) | DYRK1ACDK2CCNA2CCNA1CDK9 | |
| SCHEMBL14964303 | 0.78 | CDK2 (0.56) | DYRK1ACDK2CCNA2CCNA1CDK9 | |
| SCHEMBL14964248 | 0.78 | CDK2 (0.56) | DYRK1ACDK2CCNA2CCNA1CDK9 | |
| SCHEMBL13001908 | 0.74 | CDK2 (0.79) | DYRK1ACDK2CCNA2CCNA1CDK9 | |
| SCHEMBL3768325 | 0.74 | CDK2 (0.79) | DYRK1ACDK2CCNA2CCNA1CDK9 | |
| SCHEMBL22022251 | 0.74 | CDK2 (0.72) | DYRK1ACDK2CCNA2CCNA1CDK9 | |
| SCHEMBL3768333 | 0.74 | CDK2 (0.79) | DYRK1ACDK2CCNA2CCNA1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450342-B2 | Perharidines as CDK inhibitors | CENTRE NATIONALE DE LA RECHERCHE SCIENTIFIQUE (FR) | 2013-05-28 | — | — | US | disclosed |