Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 13/20 | 0.72 |
| ▸ | CCNA2 | P20248 | 10/20 | 0.72 |
| ▸ | CCNA1 | P78396 | 8/20 | 0.72 |
| ▸ | CDK9 | P50750 | 7/20 | 0.72 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.72 |
| ▸ | CDK5 | Q00535 | 11/20 | 0.69 |
| ▸ | DYRK1A | Q13627 | 9/20 | 0.69 |
| ▸ | CDK5R1 | Q15078 | 8/20 | 0.69 |
| ▸ | CDK1 | P06493 | 7/20 | 0.69 |
| ▸ | CCNK | O75909 | 7/20 | 0.69 |
| ▸ | CDK12 | Q9NYV4 | 7/20 | 0.69 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.69 |
| ▸ | CDK7 | P50613 | 6/20 | 0.69 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.69 |
| ▸ | CCNH | P51946 | 4/20 | 0.69 |
| ▸ | MNAT1 | P51948 | 3/20 | 0.69 |
| ▸ | CDK4 | P11802 | 3/20 | 0.69 |
| ▸ | CCND1 | P24385 | 3/20 | 0.69 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.63 |
| ▸ | GSK3B | P49841 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17628572 | 0.90 | CDK2 (0.66) | CDK2CCNA2CCNA1CDK9CCNT1 | |
| SCHEMBL19112192 | 0.88 | NPSR1 (0.67) | CDK2CCNA2CCNA1CDK9CCNT1 | |
| SCHEMBL19112178 | 0.88 | NPSR1 (0.67) | CDK2CCNA2CCNA1CDK9CCNT1 | |
| SCHEMBL30356263 | 0.88 | NPSR1 (0.67) | CDK2CCNA2CCNA1CDK9CCNT1 | |
| SCHEMBL15387124 | 0.88 | NPSR1 (0.67) | CDK2CCNA2CCNA1CDK9CCNT1 | |
| SCHEMBL19112097 | 0.88 | CDK2 (0.75) | CDK2CCNA2CCNA1CDK9CCNT1 | |
| SCHEMBL19139043 | 0.88 | CDK2 (0.75) | CDK2CCNA2CCNA1CDK9CCNT1 | |
| SCHEMBL19111955 | 0.88 | CDK2 (0.75) | CDK2CCNA2CCNA1CDK9CCNT1 | |
| Hydrochloric Acid SCHEMBL23927317 | 0.88 | NPSR1 (0.66) | CDK2CCNA2CCNA1CDK9CCNT1 | |
| Hydrochloric Acid SCHEMBL30268945 | 0.88 | NPSR1 (0.66) | CDK2CCNA2CCNA1CDK9CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11186583-B2 | 5-alkylthio-7-[(4-arylbenzyl)amino]-1(2)H-pyrazolo[4,3-d]pyrimidines for treatment of lymphoma | UNIVERZITA PALACKEHO V OLOMOUCI (CZ) | 2021-11-30 | — | — | US | disclosed |
| EP-3749670-B1 | 5-ALKYLTHIO-7-[(4-ARYLBENZYL)AMINO]-1(2)H-PYRAZOLO[4,3-D]PYRIMIDINES FOR TREATMENT OF LYMPHOMA | UNIV PALACKEHO (CZ) | 2021-10-06 | — | — | EP | disclosed |
| US-20200361943-A1 | 5-ALKYLTHIO-7-[(4-ARYLBENZYL)AMINO]-1(2)H-PYRAZOLO[4,3-D]PYRIMIDINES FOR TREATMENT OF LYMPHOMA | UNIVERZITA PALACKEHO V OLOMOUCI (CZ) | 2020-11-19 | — | — | US | disclosed |
| US-20200155521-A1 | PHARMACEUTICAL COMBINATION FOR TREATMENT OF CANCER | ARQULE, INC. | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200155521-A1 | PHARMACEUTICAL COMBINATION FOR TREATMENT OF CANCER | TP53, KRAS, VHL | CDK2 170/4885CCNA2 107/4885CCNA1 33/4885 |
| US-20200361943-A1 | 5-ALKYLTHIO-7-[(4-ARYLBENZYL)AMINO]-1(2)H-PYRAZOLO[4,3-D]PYRIMIDINES FOR TREATMENT OF LYMPHOMA | TK1, DCK, CCNK | CDK2 10/4885CCNA2 110/4885CCNA1 57/4885 |
| US-11186583-B2 | 5-alkylthio-7-[(4-arylbenzyl)amino]-1(2)H-pyrazolo[4,3-d]pyrimidines for treatment of lymphoma | TK1, DCK, CCNK | CDK2 10/4885CCNA2 110/4885CCNA1 57/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.