Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 7/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.39 |
| ▸ | PGR | P06401 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14964311 | 0.86 | PROKR1 (0.37) | MAPTTP53HTTMEN1LMNA | |
| SCHEMBL14461873 | 0.84 | MAPT (0.49) | MAPTTP53HTTMEN1LMNA | |
| SCHEMBL4971385 | 0.84 | ALDH1A1 (0.38) | MAPTTP53HTTMEN1LMNA | |
| SCHEMBL14964367 | 0.83 | TP53 (0.35) | MAPTTP53HTTMEN1LMNA | |
| SCHEMBL14964354 | 0.83 | ALDH1A1 (0.39) | MAPTTP53HTTMEN1LMNA | |
| SCHEMBL14964369 | 0.82 | ALDH1A1 (0.36) | MAPTTP53HTTMEN1LMNA | |
| SCHEMBL14964244 | 0.81 | ALDH1A1 (0.36) | MAPTTP53HTTMEN1LMNA | |
| SCHEMBL14964242 | 0.81 | ALDH1A1 (0.32) | MAPTTP53HTTMEN1LMNA | |
| SCHEMBL14964272 | 0.81 | ALDH1A1 (0.35) | MAPTTP53HTTMEN1LMNA | |
| SCHEMBL5630808 | 0.80 | MAPT (0.49) | MAPTTP53HTTMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450351-B2 | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase | INCYTE CORPORATION (US) | 2013-05-28 | — | — | US | claimed |