Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 7/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4971385 | 0.90 | ALDH1A1 (0.38) | ALDH1A1IDO1KMT2AMEN1TP53 | |
| SCHEMBL14964272 | 0.89 | ALDH1A1 (0.35) | ALDH1A1IDO1KMT2AMEN1TP53 | |
| SCHEMBL14964244 | 0.88 | ALDH1A1 (0.36) | ALDH1A1IDO1KMT2AMEN1TP53 | |
| SCHEMBL14964354 | 0.88 | ALDH1A1 (0.39) | ALDH1A1IDO1KMT2AMEN1TP53 | |
| SCHEMBL14964325 | 0.84 | IDO1 (0.35) | ALDH1A1IDO1KMT2AMEN1TP53 | |
| SCHEMBL14964299 | 0.84 | IDO1 (0.35) | ALDH1A1IDO1KMT2AMEN1TP53 | |
| SCHEMBL15100474 | 0.83 | MEN1 (0.44) | KMT2AMEN1MAPTSMN1; SMN2LMNA | |
| SCHEMBL14964280 | 0.82 | MAPT (0.46) | ALDH1A1KMT2AMEN1TP53MAPT | |
| SCHEMBL14964252 | 0.82 | IDO1 (0.45) | ALDH1A1IDO1KMT2AMEN1TP53 | |
| SCHEMBL14964327 | 0.82 | IDO1 (0.42) | IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450351-B2 | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase | INCYTE CORPORATION (US) | 2013-05-28 | — | — | US | claimed |