Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14964226 | 0.85 | STAT5B (0.41) | P2RX7HTT | |
| SCHEMBL14964185 | 0.85 | POLB (0.32) | — | |
| SCHEMBL14462399 | 0.84 | HDAC6 (0.39) | HDAC6P2RX7LMNAMAPT | |
| SCHEMBL15093281 | 0.83 | IDO1 (0.33) | — | |
| SCHEMBL14964298 | 0.82 | STAT5B (0.41) | — | |
| SCHEMBL4983469 | 0.80 | HDAC6 (0.39) | HDAC6P2RX7LMNAMAPT | |
| SCHEMBL4983463 | 0.80 | HDAC6 (0.39) | HDAC6P2RX7LMNAMAPT | |
| SCHEMBL14964276 | 0.79 | — | — | |
| SCHEMBL14964240 | 0.78 | — | — | |
| SCHEMBL4983481 | 0.78 | IDO1 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450351-B2 | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase | INCYTE CORPORATION (US) | 2013-05-28 | — | — | US | claimed |