Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15093281 | 0.90 | IDO1 (0.33) | POLBMAPK1SMN1; SMN2 | |
| SCHEMBL14964226 | 0.89 | STAT5B (0.41) | ALDH1A1 | |
| SCHEMBL14964240 | 0.87 | — | — | |
| SCHEMBL14964276 | 0.86 | — | — | |
| SCHEMBL14964288 | 0.85 | HDAC6 (0.39) | — | |
| SCHEMBL14964298 | 0.85 | STAT5B (0.41) | SMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL14964315 | 0.83 | IDO1 (0.32) | — | |
| SCHEMBL14461872 | 0.83 | MEN1 (0.39) | SMN1; SMN2CCR1CCR2ALDH1A1TSHR | |
| SCHEMBL14964181 | 0.82 | — | — | |
| SCHEMBL14964196 | 0.82 | IDO1 (0.32) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450351-B2 | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase | INCYTE CORPORATION (US) | 2013-05-28 | — | — | US | claimed |