Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT5B | P51692 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15093281 | 0.85 | IDO1 (0.33) | SMN1; SMN2IDO1 | |
| SCHEMBL14964185 | 0.85 | POLB (0.32) | SMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL14964240 | 0.85 | — | — | |
| SCHEMBL14462760 | 0.84 | SMN1; SMN2 (0.45) | STAT5BSMN1; SMN2MEN1KMT2A | |
| SCHEMBL14964181 | 0.84 | — | — | |
| SCHEMBL14964365 | 0.83 | HDAC6 (0.38) | SMN1; SMN2IDO1CNR2 | |
| SCHEMBL14964226 | 0.82 | STAT5B (0.41) | STAT5BALDH1A1 | |
| SCHEMBL14964288 | 0.82 | HDAC6 (0.39) | — | |
| SCHEMBL14964276 | 0.80 | — | — | |
| SCHEMBL4981010 | 0.80 | SMN1; SMN2 (0.44) | STAT5BSMN1; SMN2MEN1KMT2AIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450351-B2 | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase | INCYTE CORPORATION (US) | 2013-05-28 | — | — | US | claimed |