Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 9/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14964338 | 0.89 | IDO1 (0.35) | IDO1TDO2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL14964191 | 0.86 | IDO1 (0.40) | IDO1 | |
| SCHEMBL14964308 | 0.85 | IDO1 (0.33) | IDO1TDO2ALDH1A1 | |
| SCHEMBL14964196 | 0.84 | IDO1 (0.32) | IDO1TDO2ALDH1A1 | |
| SCHEMBL15093027 | 0.84 | MAPT (0.36) | IDO1TDO2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL6046626 | 0.84 | IDO1 (0.49) | IDO1TDO2ALDH1A1 | |
| SCHEMBL14964279 | 0.83 | IDO1 (0.33) | IDO1TDO2 | |
| SCHEMBL4979731 | 0.82 | IDO1 (0.34) | IDO1TDO2ALDH1A1 | |
| SCHEMBL15093281 | 0.81 | IDO1 (0.33) | IDO1TDO2SMN1; SMN2 | |
| SCHEMBL14964294 | 0.81 | IDO1 (0.33) | IDO1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450351-B2 | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase | INCYTE CORPORATION (US) | 2013-05-28 | — | — | US | claimed |