Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 11/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL15093526 | 0.93 | IDO1 (0.32) | IDO1ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL14964214 | 0.89 | ALDH1A1 (0.33) | IDO1TDO2ALDH1A1MEN1KMT2A | |
| SCHEMBL14964279 | 0.88 | IDO1 (0.33) | IDO1TDO2 | |
| SCHEMBL4980217 | 0.86 | TAAR1 (0.35) | IDO1TDO2ALDH1A1MEN1KMT2A | |
| SCHEMBL14964194 | 0.86 | SMN1; SMN2 (0.37) | IDO1TDO2ALDH1A1MEN1KMT2A | |
| SCHEMBL14964338 | 0.86 | IDO1 (0.35) | IDO1TDO2ALDH1A1MEN1KMT2A | |
| SCHEMBL15093527 | 0.85 | MAPT (0.32) | IDO1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL14964340 | 0.85 | SIGMAR1 (0.36) | IDO1ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL14964215 | 0.84 | FYN (0.40) | IDO1ALDH1A1KMT2ALMNAHTT | |
| SCHEMBL14964260 | 0.83 | EGFR (0.39) | ALDH1A1LMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450351-B2 | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase | INCYTE CORPORATION (US) | 2013-05-28 | — | — | US | claimed |
| EP-1971583-A2 | N-HYDROXYAMIDINOHETEROCYCLES AS MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | Incyte Corporation (US) | 2008-09-24 | — | — | EP | claimed |
| WO-2007075598-A2 | N-HYDROXYAMIDINOHETEROCYCLES AS MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | INCYTE CORPORATION (US) | 2007-07-05 | — | — | WO | claimed |