Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.45 |
| ▸ | STAT6 | P42226 | 1/20 | 0.44 |
| ▸ | PYGL | P06737 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | CCKBR | P32239 | 3/20 | 0.42 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CCKAR | P32238 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1931683 | 0.92 | DRD2 (0.47) | DRD2CYP51A1STAT6PYGLCNR2 | |
| SCHEMBL1931738 | 0.92 | DRD2 (0.47) | DRD2CYP51A1STAT6PYGLCNR2 | |
| SCHEMBL1931303 | 0.92 | DRD2 (0.47) | DRD2CYP51A1STAT6PYGLCNR2 | |
| SCHEMBL19856894 | 0.92 | DRD2 (0.45) | DRD2CYP51A1STAT6PYGLNPC1 | |
| SCHEMBL19856892 | 0.92 | DRD2 (0.45) | DRD2CYP51A1STAT6PYGLNPC1 | |
| SCHEMBL1929666 | 0.89 | PARP1 (0.45) | DRD2CYP51A1STAT6CNR2TAS1R3 | |
| SCHEMBL19856921 | 0.88 | CYP51A1 (0.43) | DRD2CYP51A1STAT6PYGLCCKBR | |
| SCHEMBL19856919 | 0.88 | CYP51A1 (0.43) | DRD2CYP51A1STAT6PYGLCCKBR | |
| SCHEMBL19856906 | 0.88 | DRD2 (0.45) | DRD2CYP51A1STAT6PYGLCCKBR | |
| SCHEMBL8000170 | 0.88 | DRD2 (0.46) | DRD2CYP51A1STAT6PYGLCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2312947-B1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2014-01-01 | — | — | EP | disclosed |
| US-8450484-B2 | TRPV4 antagonists | GlaxoSmithKline, LLC (US) | 2013-05-28 | — | — | US | disclosed |