SCHEMBL14964491

SCHEMBL14964491

CCCCOCCOc1cc(F)c(C#Cc2ccc(C#N)c(C#N)c2)c(F)c1

nearest known ligand 0.42

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
RARB P10826 2/20 0.42
RARA P10276 1/20 0.42
APP P05067 10/20 0.40
TSHR P16473 1/20 0.39
ACACB O00763 1/20 0.39
AR P10275 1/20 0.36
ALDH1A1 P00352 3/20 0.35
HPGD P15428 3/20 0.35
KDM4E B2RXH2 2/20 0.35
HTT P42858 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14964490 0.88 HPGD (0.42) RARBRARAAPPTSHRACACB
SCHEMBL14964492 0.87 AR (0.44) RARBRARAAPPTSHRACACB
SCHEMBL142121 0.85 RARB (0.44) RARBRARAAPPTSHRALDH1A1
SCHEMBL12477887 0.81 RARB (0.47) RARBRARAAPPTSHRALDH1A1
SCHEMBL14964554 0.81 RARB (0.47) RARBRARATSHRARALDH1A1
SCHEMBL15087654 0.78 AR (0.38) RARBRARAAPPTSHRACACB
SCHEMBL14964488 0.78 RARB (0.42) RARBRARAAPPTSHRACACB
SCHEMBL14964489 0.77 KDM4E (0.42) RARBRARAAPPTSHRALDH1A1
SCHEMBL141701 0.76 RARB (0.58) RARBRARATSHRALDH1A1HPGD
SCHEMBL12478420 0.75 SMN1; SMN2 (0.52) RARBAPPTSHRALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130170016-A1 PHOTOREFRACTIVE DEVICE CONTAINING A CHROMOPHORE-DOPED POLYMER LAYER AND ITS MANUFACTURING METHOD NITTO DENKO CORPORATION (JP) 2013-07-04 US disclosed
US-20130163086-A1 SYSTEMS AND METHODS FOR IMPROVING THE PERFORMANCE OF A PHOTOREFRACTIVE DEVICE BY UTILIZING ELECTROLYTES NITTO DENKO CORPORATION (JP) 2013-06-27 US disclosed
US-20130128339-A1 PHOTOREFRACTIVE COMPOSITION RESPONSIVE TO MULTIPLE LASER WAVELENGTHS ACROSS THE VISIBLE LIGHT SPECTRUM NITTO DENKO CORPORATION (JP) 2013-05-23 US disclosed