SCHEMBL142121

SCHEMBL142121

CCCCOCCOc1cc(F)c(C#Cc2cc(F)c(C#N)c(F)c2)c(F)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RARB P10826 2/20 0.44
RARA P10276 1/20 0.44
TSHR P16473 1/20 0.40
APP P05067 8/20 0.37
KDM4E B2RXH2 3/20 0.37
HPGD P15428 3/20 0.37
GAA P10253 1/20 0.37
MAPT P10636 1/20 0.36
ALDH1A1 P00352 3/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
MEN1 O00255 1/20 0.35
USP2 O75604 1/20 0.35
LMNA P02545 1/20 0.35
CYP3A4 P08684 1/20 0.35
MAPK1 P28482 1/20 0.35
CASP1 P29466 1/20 0.35
KMT2A Q03164 1/20 0.35
SLCO1B3 Q9NPD5 1/20 0.35
SLCO1B1 Q9Y6L6 1/20 0.35
HTT P42858 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14964489 0.92 KDM4E (0.42) RARBRARATSHRAPPKDM4E
SCHEMBL12477887 0.91 RARB (0.47) RARBRARATSHRAPPKDM4E
SCHEMBL14964488 0.90 RARB (0.42) RARBRARATSHRAPPKDM4E
SCHEMBL30933438 0.89 MAPT (0.42) RARBRARAKDM4EHPGDGAA
SCHEMBL29225925 0.88 TRPV4 (0.37) KDM4EHPGDGAAMAPTALDH1A1
SCHEMBL140747 0.87 APP (0.36) APPKDM4E
SCHEMBL15079420 0.87 RARB (0.40) RARBRARATSHRAPPKDM4E
SCHEMBL14964491 0.85 RARB (0.42) RARBRARATSHRAPPKDM4E
SCHEMBL14964550 0.85 RARB (0.45) RARBRARATSHRKDM4EHPGD
SCHEMBL30933448 0.84 MAPT (0.36) RARBRARAKDM4EHPGDGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130341573-A1 PHOTOREFRACTIVE COMPOSITION COMPRISING ELECTROLYTES IN A PHOTOREFRACTIVE LAYER AND METHOD OF MAKING THEREOF NITTO DENKO CORPORATION (JP) 2013-12-26 US disclosed
US-20130341574-A1 PHOTOREFRACTIVE COMPOSITION AND DEVICE COMPRISING THE COMPOSITION NITTO DENKO CORPORATION (JP) 2013-12-26 US disclosed
US-20130170016-A1 PHOTOREFRACTIVE DEVICE CONTAINING A CHROMOPHORE-DOPED POLYMER LAYER AND ITS MANUFACTURING METHOD NITTO DENKO CORPORATION (JP) 2013-07-04 US disclosed
US-20130163086-A1 SYSTEMS AND METHODS FOR IMPROVING THE PERFORMANCE OF A PHOTOREFRACTIVE DEVICE BY UTILIZING ELECTROLYTES NITTO DENKO CORPORATION (JP) 2013-06-27 US disclosed
WO-2013075050-A1 PHOTOREFRACTIVE DEVICE CONTAINING CARBON NANOTUBE-DOPED POLYMER LAYERS AND ITS MANUFACTURING METHOD NITTO DENKO CORPORATION (JP) 2013-05-23 WO disclosed
WO-2013075050-A1 PHOTOREFRACTIVE DEVICE CONTAINING CARBON NANOTUBE-DOPED POLYMER LAYERS AND ITS MANUFACTURING METHOD NITTO DENKO CORPORATION (JP) 2013-05-23 WO disclosed
US-20130128339-A1 PHOTOREFRACTIVE COMPOSITION RESPONSIVE TO MULTIPLE LASER WAVELENGTHS ACROSS THE VISIBLE LIGHT SPECTRUM NITTO DENKO CORPORATION (JP) 2013-05-23 US disclosed
WO-2012116105-A1 A PHOTOREFRACTIVE COMPOSITION AND DEVICE COMPRISING THE COMPOSITION NITTO DENKO CORPORATION (JP) 2012-08-30 WO disclosed
WO-2012116071-A1 PHOTOREFRACTIVE COMPOSITION COMPRISING ELECTROLYTES IN A PHOTOREFRACTIVE LAYER AND METHOD OF MAKING THEREOF NITTO DENKO CORPORATION (JP) 2012-08-30 WO disclosed
US-20120058418-A1 THREE-DIMENSIONAL HOLOGRAPHIC DISPLAY DEVICE NITTO DENKO CORPORATION (JP) 2012-03-08 US disclosed
US-20120058418-A1 THREE-DIMENSIONAL HOLOGRAPHIC DISPLAY DEVICE NITTO DENKO CORPORATION (JP) 2012-03-08 US disclosed
WO-2010141323-A1 THREE-DIMENSIONAL HOLOGRAPHIC DISPLAY DEVICE NITTO DENKO CORPORATION (JP) 2010-12-09 WO disclosed