Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.36 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | STAT3 | P40763 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14964845 | 0.85 | HTT (0.34) | HTTPIP4K2CPOLBKMT2ALMNA | |
| SCHEMBL16293243 | 0.81 | POLB (0.43) | HTTPOLBKMT2A | |
| SCHEMBL14965310 | 0.65 | HTT (0.41) | HTTPIP4K2CPOLBKMT2ANPSR1 | |
| SCHEMBL14965143 | 0.64 | — | — | |
| SCHEMBL869609 | 0.63 | KDR (0.54) | HTTPIP4K2CLMNASMN1; SMN2MAPT | |
| SCHEMBL22078037 | 0.62 | RAB9A (0.30) | SMN1; SMN2 | |
| SCHEMBL13019311 | 0.59 | HTT (0.55) | HTTPIP4K2CKMT2ALMNASMN1; SMN2 | |
| SCHEMBL13583920 | 0.58 | IRAK4 (0.77) | — | |
| SCHEMBL4433890 | 0.57 | ADRB2 (0.51) | HTTPOLBKMT2ALMNANPSR1 | |
| SCHEMBL13354291 | 0.55 | CHRNA7 (0.36) | KMT2ANPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780343-A1 | THIENO- AND FURO - PYRIMIDINES AND PYRIDINES, USEFUL AS POTASSIUM CHANNEL INHIBITORS | Xention Limited (GB) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013072694-A1 | THIENO- AND FURO - PYRIMIDINES AND PYRIDINES, USEFUL AS POTASSIUM CHANNEL INHIBITORS | XENTION LIMITED (GB) | 2013-05-23 | — | — | WO | disclosed |