Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 13/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 13/20 | 0.42 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.35 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 2/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL364225 | 0.91 | TLR8 (0.39) | TLR8TLR7TLR9KDRSYK | |
| SCHEMBL364904 | 0.80 | TLR8 (0.38) | TLR8TLR7TP53CDK9CCNT1 | |
| SCHEMBL362899 | 0.78 | TLR8 (0.40) | TLR8TLR7TLR9MAP3K12SYK | |
| SCHEMBL361659 | 0.78 | MAPT (0.40) | RORC | |
| SCHEMBL15949082 | 0.77 | — | — | |
| SCHEMBL364417 | 0.77 | — | — | |
| SCHEMBL363561 | 0.76 | AHR (0.37) | KDR | |
| SCHEMBL363791 | 0.76 | AHR (0.37) | KDR | |
| SCHEMBL364583 | 0.76 | TLR9 (0.38) | TLR8TLR7TLR9 | |
| SCHEMBL363183 | 0.75 | KIF11 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |