Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16293283 | 0.82 | KDM4E (0.53) | KDM4ETP53SMN1; SMN2 | |
| SCHEMBL14965218 | 0.80 | — | — | |
| SCHEMBL14965206 | 0.80 | SMN1; SMN2 (0.61) | KDM4ETP53SMN1; SMN2 | |
| SCHEMBL14965254 | 0.78 | — | — | |
| SCHEMBL14965339 | 0.77 | LMNA (0.67) | — | |
| SCHEMBL14965026 | 0.75 | — | — | |
| SCHEMBL14965147 | 0.74 | — | — | |
| SCHEMBL16293966 | 0.74 | KMT2A (0.70) | SMN1; SMN2 | |
| SCHEMBL14964935 | 0.74 | — | — | |
| SCHEMBL14964732 | 0.73 | SMN1; SMN2 (0.55) | KDM4ETP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780343-A1 | THIENO- AND FURO - PYRIMIDINES AND PYRIDINES, USEFUL AS POTASSIUM CHANNEL INHIBITORS | Xention Limited (GB) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013072694-A1 | THIENO- AND FURO - PYRIMIDINES AND PYRIDINES, USEFUL AS POTASSIUM CHANNEL INHIBITORS | XENTION LIMITED (GB) | 2013-05-23 | — | — | WO | disclosed |