Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16292938 | 1.00 | KMT2A (0.62) | KMT2APOLBHTTMEN1LMNA | |
| SCHEMBL16292937 | 0.86 | POLB (0.80) | KMT2APOLBHTT | |
| SCHEMBL16293966 | 0.80 | KMT2A (0.70) | KMT2APOLBHTTMEN1LMNA | |
| SCHEMBL16294397 | 0.78 | LMNA (0.72) | KMT2APOLBHTTMEN1LMNA | |
| SCHEMBL27978538 | 0.78 | KMT2A (0.58) | KMT2APOLBHTTMEN1 | |
| SCHEMBL28814474 | 0.78 | KMT2A (0.58) | KMT2APOLBHTTMEN1 | |
| SCHEMBL14970204 | 0.78 | KMT2A (0.66) | KMT2APOLBHTTMEN1LMNA | |
| SCHEMBL16294031 | 0.77 | KMT2A (0.77) | KMT2APOLBHTTMEN1LMNA | |
| SCHEMBL16293077 | 0.77 | LMNA (0.60) | KMT2AMEN1LMNAADRB3 | |
| SCHEMBL17599008 | 0.76 | KMT2A (0.77) | KMT2APOLBHTTMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780343-A1 | THIENO- AND FURO - PYRIMIDINES AND PYRIDINES, USEFUL AS POTASSIUM CHANNEL INHIBITORS | Xention Limited (GB) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013072694-A1 | THIENO- AND FURO - PYRIMIDINES AND PYRIDINES, USEFUL AS POTASSIUM CHANNEL INHIBITORS | XENTION LIMITED (GB) | 2013-05-23 | — | — | WO | disclosed |