Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | MET | P08581 | 2/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.37 |
| ▸ | CCR3 | P51677 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.36 |
| ▸ | TTK | P33981 | 2/20 | 0.36 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14965509 | 0.97 | FGFR1 (0.42) | FGFR1FGFR2FGFR3MAPK1MET | |
| SCHEMBL14965814 | 0.94 | FGFR1 (0.41) | FGFR1FGFR2FGFR3MCHR1CCR3 | |
| SCHEMBL14966145 | 0.92 | FGFR1 (0.43) | FGFR1FGFR2FGFR3METUSP30 | |
| SCHEMBL14965563 | 0.92 | MCHR1 (0.42) | FGFR1FGFR2FGFR3METMCHR1 | |
| SCHEMBL14965830 | 0.89 | AVPR1B (0.36) | MAPK1METMCHR1 | |
| SCHEMBL14965805 | 0.89 | DHODH (0.36) | METMCHR1CHRM1 | |
| SCHEMBL14965597 | 0.88 | MTOR (0.39) | MAPK1METMCHR1ACVR1 | |
| SCHEMBL14965517 | 0.88 | FGFR1 (0.40) | FGFR1FGFR2FGFR3MAPK1MET | |
| SCHEMBL14965820 | 0.87 | JAK2 (0.37) | MET | |
| SCHEMBL14965650 | 0.86 | CNR1 (0.42) | FGFR1FGFR2FGFR3MCHR1CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | claimed |
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |