Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 6/20 | 0.38 |
| ▸ | CCR3 | P51677 | 2/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.35 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.35 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | STK25 | O00506 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | GAK | O14976 | 1/20 | 0.35 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.35 |
| ▸ | BUB1 | O43683 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14965814 | 0.97 | FGFR1 (0.41) | FGFR1FGFR2FGFR3MCHR1ACVR1 | |
| SCHEMBL14965509 | 0.94 | FGFR1 (0.42) | FGFR1FGFR2FGFR3MCHR1ACVR1 | |
| SCHEMBL14965487 | 0.92 | FGFR1 (0.39) | FGFR1FGFR2FGFR3MCHR1ACVR1 | |
| SCHEMBL14965822 | 0.91 | FGFR1 (0.45) | FGFR1FGFR2FGFR3MCHR1CCR3 | |
| SCHEMBL14965970 | 0.89 | MTOR (0.39) | MCHR1ACVR1CDK4CDK6MELK | |
| SCHEMBL14966157 | 0.89 | AVPR1B (0.38) | MCHR1CDK4CDK6MERTKMELK | |
| SCHEMBL14965650 | 0.88 | CNR1 (0.42) | FGFR1FGFR2FGFR3MCHR1CCR3 | |
| SCHEMBL14966086 | 0.86 | FGFR1 (0.38) | FGFR1FGFR2FGFR3CCR3USP30 | |
| SCHEMBL14965678 | 0.86 | MTOR (0.37) | MCHR1MAP4K4CDK4CDK6MELK | |
| SCHEMBL14965844 | 0.86 | LMNA (0.35) | MCHR1JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | claimed |
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |