Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | MET | P08581 | 3/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.35 |
| ▸ | TTK | P33981 | 5/20 | 0.35 |
| ▸ | CCR3 | P51677 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14966086 | 0.94 | FGFR1 (0.38) | FGFR1FGFR2FGFR3USP30TTK | |
| SCHEMBL14965762 | 0.89 | MTOR (0.39) | MAPK1MET | |
| SCHEMBL14966213 | 0.89 | HDAC4 (0.37) | MAPK1METCYP3A4 | |
| SCHEMBL14965517 | 0.86 | FGFR1 (0.40) | FGFR1FGFR2FGFR3MAPK1MET | |
| SCHEMBL14965509 | 0.86 | FGFR1 (0.42) | FGFR1FGFR2FGFR3MAPK1MET | |
| SCHEMBL14965570 | 0.86 | JAK2 (0.36) | MET | |
| SCHEMBL14966353 | 0.86 | JAK2 (0.37) | MET | |
| SCHEMBL14965563 | 0.85 | MCHR1 (0.42) | FGFR1FGFR2FGFR3METCCR3 | |
| SCHEMBL14966153 | 0.84 | JAK2 (0.38) | METALDH1A1 | |
| SCHEMBL14965487 | 0.84 | FGFR1 (0.39) | FGFR1FGFR2FGFR3MAPK1MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | claimed |
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |