Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | MET | P08581 | 3/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | MOK | Q9UQ07 | 1/20 | 0.32 |
| ▸ | ACP1 | P24666 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14965956 | 0.94 | MTOR (0.39) | MTORCHRM3KCNH2HSP90AA1HSP90AB1 | |
| SCHEMBL14966213 | 0.91 | HDAC4 (0.37) | MAPK1METJAK2JAK1TYK2 | |
| SCHEMBL14965831 | 0.89 | FGFR1 (0.36) | MAPK1MET | |
| SCHEMBL14965570 | 0.88 | JAK2 (0.36) | MTORMETJAK2JAK1TYK2 | |
| SCHEMBL14966353 | 0.87 | JAK2 (0.37) | METJAK2JAK1TYK2JAK3 | |
| SCHEMBL14966153 | 0.86 | JAK2 (0.38) | MTORMETJAK2JAK1TYK2 | |
| SCHEMBL14965597 | 0.86 | MTOR (0.39) | MTORMAPK1METCHRM4KCNH2 | |
| SCHEMBL14966211 | 0.86 | MTOR (0.38) | MTORMETCHRM4KCNH2HSP90AA1 | |
| SCHEMBL14965639 | 0.85 | AVPR1B (0.34) | CHRM3KCNH2 | |
| SCHEMBL14966011 | 0.84 | MTOR (0.37) | MTORJAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | claimed |
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |