Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL370010 | 0.83 | GPR119 (0.44) | NAMPTMAPTTHRBKDM4EDDB1 | |
| SCHEMBL370011 | 0.83 | GPR119 (0.44) | NAMPTMAPTTHRBKDM4EDDB1 | |
| SCHEMBL368575 | 0.81 | GPBAR1 (0.51) | NAMPTIGF1RTHRBKDM4ETP53 | |
| SCHEMBL368574 | 0.81 | GPBAR1 (0.51) | NAMPTIGF1RTHRBKDM4ETP53 | |
| SCHEMBL14936621 | 0.81 | NAMPT (0.44) | NAMPTMAPTTHRBKDM4ETP53 | |
| SCHEMBL14936514 | 0.80 | GPBAR1 (0.47) | NAMPTCNR1MAPTTHRBKDM4E | |
| SCHEMBL368536 | 0.79 | NAMPT (0.43) | NAMPTMAPTTHRBKDM4EDDB1 | |
| SCHEMBL368537 | 0.79 | NAMPT (0.43) | NAMPTMAPTTHRBKDM4EDDB1 | |
| SCHEMBL1390947 | 0.78 | GPR119 (0.46) | NAMPTMAPTTHRBKDM4EDDB1 | |
| SCHEMBL363900 | 0.78 | GPR119 (0.46) | NAMPTMAPTTHRBKDM4EDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780330-A1 | 1-PYRIDAZINYL-HYDROXYIMINO- 3- PHENYL- PROPANES AS GPBAR1 AGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013072265-A1 | 1-PYRIDAZINYL-HYDROXYIMINO- 3- PHENYL- PROPANES AS GPBAR1 AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-05-23 | — | — | WO | disclosed |