Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | SMO | Q99835 | 1/20 | 0.45 |
| ▸ | PTGES | O14684 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14965812 | 0.84 | PTGES (0.56) | HDAC6CA1CA2CA7CA14 | |
| SCHEMBL6629351 | 0.84 | ROCK2 (0.46) | ROCK2ROCK1 | |
| SCHEMBL9932144 | 0.83 | PTGES (0.57) | HDAC6CA1CA2CA7CA14 | |
| SCHEMBL19954234 | 0.83 | ROCK2 (0.44) | ROCK2ROCK1HPGD | |
| SCHEMBL12634613 | 0.83 | ROCK2 (0.49) | ROCK2ROCK1LMNAHPGD | |
| SCHEMBL18810200 | 0.82 | CA1 (0.48) | HDAC6CA1CA2CA7CA14 | |
| SCHEMBL20551918 | 0.82 | HDAC6 (0.46) | HDAC6CA1CA2CA7CA14 | |
| Hydrochloric Acid SCHEMBL29416994 | 0.81 | CA1 (0.47) | HDAC6CA1CA2CA7CA14 | |
| Hydrochloric Acid SCHEMBL20489837 | 0.81 | CA1 (0.47) | HDAC6CA1CA2CA7CA14 | |
| SCHEMBL17790264 | 0.81 | HPGD (0.51) | ROCK2ROCK1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013072825-A1 | PHTALAZINONE DERIVATIVES AS MPEGS -1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2013-05-23 | — | — | WO | disclosed |
| WO-2013072825-A1 | PHTALAZINONE DERIVATIVES AS MPEGS -1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2013-05-23 | — | — | WO | disclosed |