Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.37 |
| ▸ | HRH2 | P25021 | 5/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 9/20 | 0.35 |
| ▸ | IKBKE | Q14164 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14967025 | 0.89 | HRH3 (0.34) | KDM4EHRH3HRH2NPC1RAB9A | |
| SCHEMBL8136170 | 0.80 | SLC9A1 (0.39) | KDM4ENPC1RAB9AALDH1A1HPGD | |
| SCHEMBL1680507 | 0.72 | KDM4E (0.58) | KDM4ENPC1RAB9AALDH1A1HPGD | |
| SCHEMBL7911308 | 0.70 | SLC9A1 (0.37) | KDM4EHRH3HRH2NPC1RAB9A | |
| SCHEMBL7916696 | 0.70 | KDM4E (0.50) | KDM4ENPC1RAB9AALDH1A1HPGD | |
| SCHEMBL9406603 | 0.70 | HRH3 (0.42) | KDM4EHRH3HRH2HSD17B10MAPT | |
| Fumaric Acid SCHEMBL7912855 | 0.68 | SMN1; SMN2 (0.33) | KDM4ENPC1RAB9AALDH1A1MAPT | |
| Maleic Acid SCHEMBL7912919 | 0.68 | SMN1; SMN2 (0.33) | KDM4ENPC1RAB9AALDH1A1MAPT | |
| SCHEMBL10286354 | 0.68 | HSD17B10 (0.36) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL1998766 | 0.67 | SLC9A1 (0.39) | KDM4ERAB9AALDH1A1HSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013072882-A1 | 2 -AMINO- 1, 8 -NAPHTHYRIDINE-3 -CARBOXAMIDE DERIVATIVES AS ANTIMICROBIAL AGENTS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-23 | — | — | WO | disclosed |