Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | RXRA | P19793 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL7912919 | 1.00 | SMN1; SMN2 (0.33) | SMN1; SMN2LMNAMAPTSLC9A1ALDH1A1 | |
| SCHEMBL7911308 | 0.94 | SLC9A1 (0.37) | SMN1; SMN2LMNAMAPTSLC9A1ALDH1A1 | |
| SCHEMBL1998766 | 0.90 | SLC9A1 (0.39) | SMN1; SMN2LMNAMAPTSLC9A1ALDH1A1 | |
| Cadaverine Tartrate SCHEMBL7911205 | 0.89 | SLC9A1 (0.33) | SLC9A1 | |
| SCHEMBL7902762 | 0.82 | SLC9A1 (0.37) | SMN1; SMN2LMNAMAPTSLC9A1ALDH1A1 | |
| SCHEMBL8132938 | 0.81 | SLC9A1 (0.36) | SLC9A1 | |
| Maleic Acid SCHEMBL7916788 | 0.81 | SLC9A1 (0.54) | SMN1; SMN2LMNAMAPTSLC9A1ALDH1A1 | |
| SCHEMBL7910351 | 0.80 | SLC9A1 (0.35) | SMN1; SMN2SLC9A1ALDH1A1KDM4E | |
| SCHEMBL7903007 | 0.79 | SLC9A1 (0.39) | SMN1; SMN2LMNAMAPTSLC9A1ALDH1A1 | |
| SCHEMBL7913174 | 0.78 | SLC9A1 (0.38) | SMN1; SMN2LMNAMAPTSLC9A1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6258829-B1 | ANTIARRTHMIA AGENTS AND CARDIOVASCULAR DISORDERS | TOA EIYO LTD. (JP) | 2001-07-10 | — | — | US | disclosed |
| EP-0972767-A1 | CYCLOALKA[b]PYRIDINE-3-CARBONYLGUANIDINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND DRUGS CONTAINING THE SAME | TOA EIYO LTD. (JP) | 2000-01-19 | — | — | EP | disclosed |