Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.56 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MDH1 | P40925 | 1/20 | 0.47 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14966389 | 0.92 | TDP1 (0.60) | TDP1L3MBTL1CYP4A11HPGDPOLB | |
| SCHEMBL14966689 | 0.87 | HPGD (0.56) | TDP1L3MBTL1HPGDPOLBKDM4E | |
| SCHEMBL6119786 | 0.84 | RAB9A (0.59) | TDP1L3MBTL1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL14966681 | 0.81 | MAPT (0.74) | TDP1L3MBTL1CYP4A11CYP4F2MAPT | |
| SCHEMBL4361268 | 0.80 | MAPT (0.72) | TDP1L3MBTL1CYP4A11CYP4F2MAPT | |
| SCHEMBL10337881 | 0.79 | TDP1 (0.81) | TDP1L3MBTL1HPGDPOLBMAPT | |
| SCHEMBL4359850 | 0.79 | MAPT (0.70) | TDP1L3MBTL1CYP4A11CYP4F2MAPT | |
| SCHEMBL14967541 | 0.79 | TDP1 (0.56) | TDP1L3MBTL1HPGDPOLBKDM4E | |
| SCHEMBL4376261 | 0.79 | MAPT (0.70) | TDP1L3MBTL1CYP4A11CYP4F2MAPT | |
| SCHEMBL14967130 | 0.78 | MAPT (0.54) | CYP4A11CYP4F2MAPTRAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780014-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | Constellation Pharmaceuticals, Inc. (US) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013075083-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2013-05-23 | — | — | WO | disclosed |