Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18839753 | 0.80 | KDM4E (0.39) | ATMKDM4EKMT2APOLBALDH1A1 | |
| SCHEMBL18839682 | 0.79 | KDM4E (0.41) | ATMKDM4EKMT2APOLBALDH1A1 | |
| SCHEMBL17686526 | 0.79 | ALDH1A1 (0.47) | ATMKDM4EKMT2APOLBALDH1A1 | |
| SCHEMBL17627024 | 0.77 | ALDH1A1 (0.50) | ATMKDM4EKMT2APOLBALDH1A1 | |
| SCHEMBL3538772 | 0.76 | ALDH1A1 (0.54) | ATMKDM4EKMT2APOLBALDH1A1 | |
| SCHEMBL20518698 | 0.76 | PKM (0.44) | ATMKDM4EKMT2APOLBALDH1A1 | |
| SCHEMBL18839794 | 0.76 | PKM (0.44) | ATMKDM4EKMT2APOLBALDH1A1 | |
| SCHEMBL17627022 | 0.76 | ATM (0.49) | ATMKDM4EKMT2APOLBALDH1A1 | |
| SCHEMBL18839887 | 0.74 | KDM4E (0.38) | ATMKDM4EKMT2APOLBALDH1A1 | |
| SCHEMBL8215669 | 0.74 | HPGD (0.70) | KDM4EKMT2APOLBALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780322-A1 | METHODS AND COMPOSITIONS ASSOCIATED WITH THE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR | Ligand Pharmaceuticals Inc. (US) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013074459-A1 | METHODS AND COMPOSITIONS ASSOCIATED WITH THE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR | LIGAND PHARMACEUTICALS, INC. (US) | 2013-05-23 | — | — | WO | disclosed |