Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14969105 | 0.81 | KDM4E (0.56) | KDM4EALDH1A1SMN1; SMN2HPGDNPC1 | |
| SCHEMBL14967156 | 0.80 | KDM4E (0.55) | KDM4EALDH1A1SMN1; SMN2HPGDNPC1 | |
| SCHEMBL14967097 | 0.78 | ALDH1A1 (0.55) | KDM4EALDH1A1SMN1; SMN2HPGDNPC1 | |
| SCHEMBL1680790 | 0.74 | KDM4E (0.95) | KDM4EALDH1A1SMN1; SMN2HPGDNPC1 | |
| SCHEMBL10271344 | 0.73 | KDM4E (0.70) | KDM4EALDH1A1SMN1; SMN2HPGDNPC1 | |
| SCHEMBL14967069 | 0.73 | KDM4E (0.70) | KDM4EALDH1A1SMN1; SMN2HPGDNPC1 | |
| SCHEMBL10286560 | 0.73 | KDM4E (0.67) | KDM4EALDH1A1SMN1; SMN2HPGDNPC1 | |
| SCHEMBL14966614 | 0.73 | TBK1 (0.33) | TBK1 | |
| SCHEMBL2902560 | 0.69 | KDM4E (0.45) | KDM4EALDH1A1SMN1; SMN2HPGDNPC1 | |
| SCHEMBL2902646 | 0.69 | KDM4E (0.45) | KDM4EALDH1A1SMN1; SMN2HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013072882-A1 | 2 -AMINO- 1, 8 -NAPHTHYRIDINE-3 -CARBOXAMIDE DERIVATIVES AS ANTIMICROBIAL AGENTS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-23 | — | — | WO | disclosed |