Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9670057 | 0.87 | KDM4E (0.44) | KDM4ELMNAPKMIDO1HSD17B10 | |
| SCHEMBL14966437 | 0.83 | KDM4E (0.44) | KDM4ELMNAPKMIDO1HSD17B10 | |
| SCHEMBL14966297 | 0.79 | KDM4E (0.41) | KDM4ELMNAPKMIDO1HSD17B10 | |
| SCHEMBL10370416 | 0.78 | KDM4E (0.48) | KDM4ELMNAPKMIDO1RAB9A | |
| SCHEMBL30867279 | 0.77 | KDM4E (0.50) | KDM4ELMNAPKMIDO1HSD17B10 | |
| SCHEMBL10370033 | 0.76 | KDM4E (0.49) | KDM4ELMNAPKMIDO1RAB9A | |
| SCHEMBL2371732 | 0.76 | KDM4E (0.50) | KDM4ELMNAPKMIDO1RAB9A | |
| SCHEMBL30206229 | 0.76 | KDM4E (0.50) | KDM4ELMNAPKMIDO1RAB9A | |
| SCHEMBL14966788 | 0.76 | RAB9A (0.45) | KDM4ELMNAIDO1HSD17B10TP53 | |
| SCHEMBL10370830 | 0.75 | KDM4E (0.55) | KDM4ELMNAPKMIDO1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013072882-A1 | 2 -AMINO- 1, 8 -NAPHTHYRIDINE-3 -CARBOXAMIDE DERIVATIVES AS ANTIMICROBIAL AGENTS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-23 | — | — | WO | disclosed |