Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HCAR3 | P49019 | 7/20 | 0.45 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.45 |
| ▸ | LDHA | P00338 | 1/20 | 0.45 |
| ▸ | P4HA1 | P13674 | 2/20 | 0.43 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 1/20 | 0.42 |
| ▸ | MIF | P14174 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14967482 | 0.88 | ALDH1A1 (0.47) | GCKKMT2APOLBHCAR3MAPT | |
| SCHEMBL14966276 | 0.87 | KDM4E (0.50) | GCKKMT2APOLBMAPT | |
| SCHEMBL3646089 | 0.81 | KMT2A (0.54) | KMT2APOLBALKBH1PKMRXRA | |
| SCHEMBL9952589 | 0.81 | MAP4K4 (0.46) | KMT2ARXRARXRB | |
| SCHEMBL17319351 | 0.78 | POLB (0.50) | POLBMAPT | |
| SCHEMBL30043919 | 0.77 | HCAR3 (0.56) | HCAR3LDHAP4HA1P4HTMMAPT | |
| SCHEMBL100969 | 0.77 | HCAR3 (0.56) | HCAR3LDHAP4HA1P4HTMMAPT | |
| SCHEMBL14966974 | 0.76 | POLB (0.49) | KMT2APOLBMAPTPKM | |
| SCHEMBL14967524 | 0.76 | KMT2A (0.59) | GCKKMT2AALKBH1PKMRXRA | |
| SCHEMBL14966382 | 0.76 | KMT2A (0.59) | GCKKMT2AALKBH1PKMRXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9206128-B2 | Modulators of methyl modifying enzymes, compositions and uses thereof | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2015-12-08 | — | — | US | disclosed |
| EP-2780014-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | Constellation Pharmaceuticals, Inc. (US) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013075083-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2013-05-23 | — | — | WO | disclosed |
| WO-2013075083-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2013-05-23 | — | — | WO | disclosed |