Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | OGG1 | O15527 | 1/20 | 0.36 |
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.30 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.30 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9988508 | 0.80 | EPHX1 (0.37) | — | |
| SCHEMBL29201981 | 0.79 | PTGS1 (0.37) | ALDH1A1MAPTSMN1; SMN2KDM4ETSHR | |
| SCHEMBL10957480 | 0.78 | POLB (0.40) | ALDH1A1MAPTSMN1; SMN2LMNACXCR1 | |
| SCHEMBL27598745 | 0.71 | — | — | |
| SCHEMBL15825344 | 0.71 | SCN10A (0.34) | — | |
| SCHEMBL24015855 | 0.70 | ACACB (0.39) | — | |
| SCHEMBL4794475 | 0.70 | PTGER3 (0.33) | — | |
| SCHEMBL4199271 | 0.70 | ADORA2A (0.36) | GAAMAPTHTTSMN1; SMN2LMNA | |
| SCHEMBL15745601 | 0.69 | CYP1A2 (0.55) | ALDH1A1GAACTSDHTTSMN1; SMN2 | |
| SCHEMBL21378747 | 0.69 | CYP1A2 (0.55) | ALDH1A1GAACTSDHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780322-A1 | METHODS AND COMPOSITIONS ASSOCIATED WITH THE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR | Ligand Pharmaceuticals Inc. (US) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013074459-A1 | METHODS AND COMPOSITIONS ASSOCIATED WITH THE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR | LIGAND PHARMACEUTICALS, INC. (US) | 2013-05-23 | — | — | WO | disclosed |