Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.46 |
| ▸ | HBB | P68871 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA6 | P23280 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12518720 | 0.81 | KDM4E (0.47) | KDM4EPOLBRAB9AMEN1KMT2A | |
| SCHEMBL2303325 | 0.81 | KDM4E (0.50) | KDM4EPOLBRAB9AMEN1KMT2A | |
| SCHEMBL30114254 | 0.81 | KDM4E (0.50) | KDM4EPOLBRAB9AMEN1KMT2A | |
| SCHEMBL9562 | 0.80 | KDM4E (0.46) | KDM4EPOLBRAB9AMEN1KMT2A | |
| SCHEMBL10538 | 0.80 | KDM4E (0.46) | KDM4EPOLBRAB9AMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL25269873 | 0.79 | KDM4E (0.49) | KDM4EPOLBRAB9AMEN1KMT2A | |
| SCHEMBL3824044 | 0.78 | KDM4E (0.43) | KDM4EPOLBRAB9AMEN1KMT2A | |
| SCHEMBL12364150 | 0.78 | CCR1 (0.44) | KDM4EPOLBRAB9AMEN1KMT2A | |
| SCHEMBL113293 | 0.77 | — | — | |
| SCHEMBL29536663 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1967519-B1 | 3,4-DIHYDROBENZOXAZINE COMPOUND AND INHIBITOR OF VANILLOID RECEPTOR TYPE 1 (VR1) ACTIVITY | JAPAN TOBACCO INC (JP) | 2012-09-05 | — | — | EP | disclosed |
| US-20110212952-A1 | 3,4-DIHYDROBENZOXAZINE COMPOUNDS AND INHIBITORS OF VANILLOID RECEPTOR SUBTYPE 1 (VRI) ACTIVITY | JAPAN TOBACCO INC. (JP) | 2011-09-01 | — | — | US | disclosed |
| US-7906508-B2 | 3,4-dihydrobenzoxazine compounds and inhibitors of vanilloid receptor subtype 1 (VRI) activity | JAPAN TOBACCO INC. (JP) | 2011-03-15 | — | — | US | disclosed |
| CN-101351462-A | 3,4-dihydrobenzoxazine compound and inhibitor of vanilloid receptor type 1(VR1) activity | JAPAN TOBACCO INC (JP) | 2009-01-21 | — | — | CN | disclosed |
| EP-1967519-A1 | 3,4-DIHYDROBENZOXAZINE COMPOUND AND INHIBITOR OF VANILLOID RECEPTOR TYPE 1 (VR1) ACTIVITY | JAPAN TOBACCO INC. (JP) | 2008-09-10 | — | — | EP | disclosed |
| US-20070149517-A1 | 3,4-DIHYDROBENZOXAZINE COMPOUNDS AND INHIBITORS OF VANILLOID RECEPTOR SUBTYPE 1 (VRI) ACTIVITY | JAPAN TOBACCO INC. (JP) | 2007-06-28 | — | — | US | disclosed |
| US-4004011-A | PROLACTIN SECRETION INHIBITORS | SANDOZ LTD. (CH) | 1977-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149517-A1 | 3,4-DIHYDROBENZOXAZINE COMPOUNDS AND INHIBITORS OF VANILLOID RECEPTOR SUBTYPE 1 (VRI) ACTIVITY | TRPV3, TRPV1, TRPV5 | KDM4E 3274/4885POLB 3992/4885RAB9A 3773/4885 |
| US-20110212952-A1 | 3,4-DIHYDROBENZOXAZINE COMPOUNDS AND INHIBITORS OF VANILLOID RECEPTOR SUBTYPE 1 (VRI) ACTIVITY | TRPV3, TRPV1, TRPV5 | KDM4E 3274/4885POLB 3992/4885RAB9A 3773/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.