TRPV5

Transient receptor potential cation channel subfamily V member 5 · Q9NQA5 · TRPV5 on Sugi Atlas →

896 patent compounds predicted against TRPV5, 789 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Tetrahydrocannabivarin (SCHEMBL245827)	1.00	1/20
Tetrahydrocannabivarin (SCHEMBL6856739)	1.00	1/20
Tetrahydrocannabivarin (SCHEMBL15827163)	1.00	1/20
Tetrahydrocannabivarin (SCHEMBL18371743)	1.00	1/20
Tetrahydrocannabivarin (SCHEMBL21363566)	1.00	1/20
Tetrahydrocannabivarin (SCHEMBL25731794)	1.00	1/20
Tetrahydrocannabivarin (SCHEMBL25731819)	1.00	1/20
Tetrahydrocannabivarin (SCHEMBL29350511)	1.00	1/20
Tetrahydrocannabivarin (SCHEMBL29422123)	1.00	1/20
SCHEMBL13214127	0.88	1/20
SCHEMBL18909070	0.88	1/20
SCHEMBL22705480	0.88	1/20
SCHEMBL24351964	0.88	1/20
SCHEMBL25098270	0.88	1/20
SCHEMBL29351497	0.88	1/20
SCHEMBL29422046	0.88	1/20
Dronabinol (SCHEMBL4609)	0.86	1/20
Dronabinol (SCHEMBL1114909)	0.86	1/20
Dronabinol (SCHEMBL1227386)	0.86	1/20
Dronabinol (SCHEMBL3686519)	0.86	1/20

Clinical trials — most relevant to TRPV5 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
TRPV Expression in Subjects With Sensitive Skin	PHASE4	UNKNOWN
Mechanisms of Capsaicin Treatment in Idiopathic Rhinitis Patients and Controls	PHASE4	COMPLETED
The Re-Prosper HF Study	PHASE2/PHASE3	COMPLETED
Botulinum Toxin Injections for Oral Neuropathic Pain	PHASE3	COMPLETED
Suzetrigine in Total Hip Arthroplasty	PHASE3	RECRUITING
Botulinum Toxin A for the Treatment of Chemotherapy Induced Peripheral Neuropathy	PHASE2	RECRUITING
Palmitoylethanolamide for Chronic Inflammatory Pain Conditions	PHASE2	RECRUITING
Study Designed to Evaluate Safety and Efficacy of 1% Topical Formulation of KM-001 on Type 1 Punctate Palmoplantar Keratoderma or Pachyonychia Congenita Diseases	PHASE1	COMPLETED
Assessment of KM-001 - Safety, Tolerability, and Efficacy in Patients With PPPK1 or PC	PHASE1	COMPLETED
Do Acid Sensing Ion Channels Contribute to Heartburn?	PHASE1	COMPLETED
Mechanism of Human Cold Pain Perception - Involvement of TRPA1, TRPM8, Nav1.7 and Nav1.8	EARLY_PHASE1	COMPLETED
Mechanisms of Human Heat Perception - Involvement of TRPA1, TRPV1 and TRPM3	EARLY_PHASE1	COMPLETED
Menthol Stimulation of Brown Adipose Tissue in Humans: Aim 1	EARLY_PHASE1	RECRUITING
Concentration of Receptors With Affinity for Cannabidiol and Cannabinol and the Effect on Chronic Orofacial Pain of Muscle Origin	nan	ENROLLING_BY_INVITATION
Relationship Between Polymorphisms of TRPV1 and KCC2 Gene in Children With Febrile Seizures	nan	COMPLETED
The Natural History of TRPV4 Neuropathy	nan	RECRUITING
Qutenza 8% Capsaicin Topical System for the Treatment of Neuropathic Axial Lower Back Pain and Lumbosacral Radiculopathy	nan	ENROLLING_BY_INVITATION
Dissecting the Heterogeneity of Oral Cancer Pain	nan	UNKNOWN
Factors Affecting Salt Intake in Young Adults	nan	UNKNOWN
Neurogenic Mechanisms in Burning Mouth Syndrome	nan	COMPLETED
Identification of TRP Channels as New Potential Therapeutic Targets in Primary and Secondary Raynaud's Phenomenon.	nan	COMPLETED
An Investigation Into the Mechanism of Inhalation Cough Challenge	nan	COMPLETED
Expressions of TRPV1 in Airway of Asthmatics	nan	WITHDRAWN
Nutrition for Migraine Prevention	nan	COMPLETED
Effect of Boswellia Serrata on Pain Intensity, Central and Peripheral Sensitization, and Pain Modulation in Healthy Volunteers	nan	RECRUITING
Characterization of New Human Models of Non-histaminergic Itch and Their Interaction With the TRPM8 Receptor	nan	COMPLETED
A Study on the Mechanism of Cough Hypersensitivity	nan	UNKNOWN
Effects of Photobiomodulation on the Innate Immune System of Neonates and Infants With Bronchiolitis	nan	UNKNOWN
Classical Trigeminal Neuralgia and Sodium Channel Mutations	nan	COMPLETED
Defining TRPV4 Contribution of Schwann Cells to Oral Cancer Pain	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a TRPV5 binder may also engage these)

Protein	Name	Similarity
Q9R186	—	1.000	Q9R186 →
Q9XSM3	—	1.000	Q9XSM3 →
P69744	—	0.999	P69744 →
TRPV6	Transient receptor potential cation channel subfamily V member 6	0.999	landscape →
Q9JIP0	—	0.997	Q9JIP0 →
Q6RX08	—	0.996	Q6RX08 →
Q91WD2	—	0.994	Q91WD2 →
TRPV1	Transient receptor potential cation channel subfamily V member 1	0.992	landscape →
P19334	—	0.992	P19334 →
Q61056	—	0.992	Q61056 →
Q697L1	—	0.991	Q697L1 →
Q704Y3	—	0.991	Q704Y3 →
O62852	—	0.989	O62852 →
O95477	—	0.989	O95477 →
A0A1D5PXA5	—	0.988	A0A1D5PXA5 →
Q52T38	—	0.988	Q52T38 →
Q9ERZ8	—	0.988	Q9ERZ8 →
ADCY2	Adenylate cyclase type 2	0.987	landscape →
Q9EPK8	—	0.987	Q9EPK8 →
Q6R5A3	—	0.987	Q6R5A3 →
Q38998	—	0.987	Q38998 →
Q9MYV9	—	0.986	Q9MYV9 →
Q9WUD2	—	0.986	Q9WUD2 →
Q9ULH0	—	0.985	Q9ULH0 →
TRPV2	Transient receptor potential cation channel subfamily V member 2	0.985	landscape →
Q9QUQ5	—	0.985	Q9QUQ5 →
TRPC1	Short transient receptor potential channel 1	0.985	landscape →
O35433	—	0.985	O35433 →
P34586	—	0.985	P34586 →
Q9SCX5	—	0.984	Q9SCX5 →