Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C18 | P33260 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.33 |
| ▸ | PAICS | P22234 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1496935 | 0.94 | UTS2R (0.38) | CYP1A2CYP2C18CYP2C19KCNH2HDAC3 | |
| SCHEMBL1497095 | 0.92 | AKT1 (0.35) | CYP1A2CYP2C19KCNH2HDAC3HDAC2 | |
| SCHEMBL1497031 | 0.90 | AKT1 (0.35) | CYP1A2CYP2C18CYP2C19KCNH2AKT1 | |
| SCHEMBL1497007 | 0.88 | ROCK2 (0.37) | KCNH2HDAC3HDAC2AKT1FLT3 | |
| SCHEMBL1497013 | 0.86 | CSF1R (0.36) | HDAC3AKT1CSF1RFLT3MAPK1 | |
| SCHEMBL1482305 | 0.84 | UTS2R (0.43) | HDAC2UTS2R | |
| SCHEMBL1497137 | 0.84 | HDAC3 (0.39) | CYP1A2CYP2C18CYP2C19KCNH2HDAC3 | |
| SCHEMBL1497039 | 0.84 | CYP1A2 (0.37) | CYP1A2CYP2C18CYP2C19KCNH2HDAC3 | |
| SCHEMBL1496991 | 0.84 | CSF1R (0.35) | CSF1RFLT3DYRK1AMAPK14 | |
| SCHEMBL1482712 | 0.83 | UTS2R (0.38) | HDAC3HDAC2AKT1MAPK1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2292611-B1 | NOVEL THIOPHENEDIAMINE DERIVATIVE HAVING UREA STRUCTURE | SANTEN PHARMACEUTICAL CO LTD (JP) | 2012-07-25 | — | — | EP | disclosed |
| EP-2292611-A1 | NOVEL THIOPHENEDIAMINE DERIVATIVE HAVING UREA STRUCTURE | Santen Pharmaceutical Co., Ltd (JP) | 2011-03-09 | — | — | EP | disclosed |