Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | AKT2 | P31751 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 8/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1497095 | 0.96 | AKT1 (0.35) | ROCK2AKT1AKT2KCNH2AKT3 | |
| SCHEMBL4233251 | 0.93 | HDAC1 (0.39) | ROCK2AKT1AKT2KCNH2AKT3 | |
| SCHEMBL1497031 | 0.93 | AKT1 (0.35) | ROCK2AKT1AKT2KCNH2AKT3 | |
| SCHEMBL4222628 | 0.91 | HDAC1 (0.38) | EPHX2HDAC3HDAC2 | |
| SCHEMBL1496935 | 0.89 | UTS2R (0.38) | ROCK2AKT1AKT2KCNH2AKT3 | |
| SCHEMBL1496936 | 0.88 | CYP1A2 (0.38) | AKT1KCNH2HDAC3HDAC2FLT3 | |
| SCHEMBL1496958 | 0.87 | CD274 (0.39) | EPHX2 | |
| SCHEMBL1482270 | 0.85 | SMN1; SMN2 (0.36) | ROCK2AKT1AKT2KCNH2AKT3 | |
| SCHEMBL3230179 | 0.85 | JAK2 (0.38) | EPHX2MAPTLMNAGRM4 | |
| SCHEMBL1497209 | 0.84 | ALDH1A1 (0.41) | HIF1AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2292611-B1 | NOVEL THIOPHENEDIAMINE DERIVATIVE HAVING UREA STRUCTURE | SANTEN PHARMACEUTICAL CO LTD (JP) | 2012-07-25 | — | — | EP | disclosed |
| EP-2292611-A1 | NOVEL THIOPHENEDIAMINE DERIVATIVE HAVING UREA STRUCTURE | Santen Pharmaceutical Co., Ltd (JP) | 2011-03-09 | — | — | EP | disclosed |