Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | ADRB3 | P13945 | 8/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 7/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 6/20 | 0.51 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6836284 | 0.93 | KMT2A (0.56) | KMT2AMEN1ADRB3ADRB2ADRB1 | |
| SCHEMBL6836255 | 0.92 | KMT2A (0.62) | KMT2AMEN1ADRB3ADRB2ADRB1 | |
| SCHEMBL6836231 | 0.86 | LMNA (0.56) | KMT2AMEN1ADRB3ADRB2ADRB1 | |
| SCHEMBL6836170 | 0.84 | KMT2A (0.51) | KMT2AMEN1ADRB3ADRB2ADRB1 | |
| SCHEMBL6832454 | 0.80 | ADRB2 (0.52) | KMT2AMEN1ADRB3ADRB2ADRB1 | |
| SCHEMBL1921231 | 0.80 | LMNA (0.58) | KMT2A | |
| SCHEMBL23599413 | 0.79 | CKS1B (0.54) | KMT2AMEN1ADRB3ADRB2ADRB1 | |
| SCHEMBL27978782 | 0.76 | LMNA (0.65) | KMT2AMEN1ADRB3ADRB2ADRB1 | |
| SCHEMBL3339299 | 0.75 | ADRB2 (0.49) | ADRB3ADRB2ADRB1 | |
| SCHEMBL14965503 | 0.73 | LMNA (0.67) | KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780343-A1 | THIENO- AND FURO - PYRIMIDINES AND PYRIDINES, USEFUL AS POTASSIUM CHANNEL INHIBITORS | Xention Limited (GB) | 2014-09-24 | — | — | EP | claimed |
| WO-2013072694-A1 | THIENO- AND FURO - PYRIMIDINES AND PYRIDINES, USEFUL AS POTASSIUM CHANNEL INHIBITORS | XENTION LIMITED (GB) | 2013-05-23 | — | — | WO | claimed |
| EP-2780343-A1 | THIENO- AND FURO - PYRIMIDINES AND PYRIDINES, USEFUL AS POTASSIUM CHANNEL INHIBITORS | Xention Limited (GB) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013072694-A1 | THIENO- AND FURO - PYRIMIDINES AND PYRIDINES, USEFUL AS POTASSIUM CHANNEL INHIBITORS | XENTION LIMITED (GB) | 2013-05-23 | — | — | WO | disclosed |