Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UTS2R | Q9UKP6 | 10/20 | 0.42 |
| ▸ | AURKA | O14965 | 3/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 5/20 | 0.38 |
| ▸ | KIT | P10721 | 3/20 | 0.38 |
| ▸ | TEK | Q02763 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 2/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.36 |
| ▸ | LCK | P06239 | 2/20 | 0.36 |
| ▸ | FYN | P06241 | 2/20 | 0.36 |
| ▸ | CSF1R | P07333 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1496979 | 0.95 | UTS2R (0.47) | UTS2RAURKAALKMEN1KMT2A | |
| SCHEMBL1497122 | 0.91 | UTS2R (0.42) | UTS2RAURKAALKKDRKIT | |
| SCHEMBL4224028 | 0.90 | UTS2R (0.43) | UTS2RAURKAALKMEN1KMT2A | |
| SCHEMBL1496848 | 0.88 | UTS2R (0.42) | UTS2RAURKAALKMEN1KMT2A | |
| SCHEMBL1482712 | 0.88 | UTS2R (0.38) | UTS2RROCK1ROCK2 | |
| SCHEMBL1496896 | 0.86 | UTS2R (0.47) | UTS2RAURKAKITAURKBROCK1 | |
| SCHEMBL1497138 | 0.86 | UTS2R (0.46) | UTS2RROCK1ROCK2 | |
| SCHEMBL2382361 | 0.85 | UTS2R (0.49) | UTS2RMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL1497004 | 0.85 | UTS2R (0.62) | UTS2RAURKAALDH1A1SMN1; SMN2AURKB | |
| SCHEMBL1497151 | 0.83 | UTS2R (0.42) | UTS2RMEN1KMT2AALDH1A1ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2292611-B1 | NOVEL THIOPHENEDIAMINE DERIVATIVE HAVING UREA STRUCTURE | SANTEN PHARMACEUTICAL CO LTD (JP) | 2012-07-25 | — | — | EP | disclosed |
| EP-2292611-A1 | NOVEL THIOPHENEDIAMINE DERIVATIVE HAVING UREA STRUCTURE | Santen Pharmaceutical Co., Ltd (JP) | 2011-03-09 | — | — | EP | disclosed |