SCHEMBL149717

SCHEMBL149717

C[Si]1(C)CCCN1c1ccc(C#N)nc1

nearest known ligand 0.35

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
USP14 P54578 2/20 0.35
OPRM1 P35372 3/20 0.34
OPRL1 P41146 3/20 0.34
MEN1 O00255 1/20 0.32
AOC3 Q16853 2/20 0.31
PDE4B Q07343 1/20 0.31
PDE4D Q08499 1/20 0.31
ITGAL P20701 1/20 0.31
AR P10275 2/20 0.31
NAMPT P43490 1/20 0.31
CHEK1 O14757 1/20 0.31
ACHE P22303 1/20 0.31
PARP1 P09874 1/20 0.31
TNK2 Q07912 1/20 0.31
TNK1 Q13470 1/20 0.31
EGLN2 Q96KS0 1/20 0.30
GRIN2B Q13224 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL148508 0.80 PANK3 (0.33)
SCHEMBL151691 0.78 OPRM1 (0.36) USP14OPRM1OPRL1MEN1AOC3
SCHEMBL148400 0.76 KDM4E (0.42) CHEK1
SCHEMBL27909230 0.73 CHRNB2 (0.44) USP14MEN1AOC3ARCHEK1
SCHEMBL151047 0.73 MAPT (0.46) USP14MEN1AOC3ARPARP1
SCHEMBL151160 0.71 MAPT (0.49) USP14MEN1AOC3NAMPTPARP1
SCHEMBL148390 0.71 MAPT (0.49) USP14MEN1AOC3NAMPTPARP1
SCHEMBL29612110 0.69 CHEK1 (0.51) MEN1AOC3CHEK1ACHE
SCHEMBL151032 0.69 CHEK1 (0.51) MEN1AOC3CHEK1ACHE
SCHEMBL1479659 0.68

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2526149-B1 POLYMERS FUNCTIONALIZED WITH NITRILE COMPOUNDS CONTAINING A PROTECTED AMINO GROUP BRIDGESTONE CORP (JP) 2017-03-01 EP disclosed
US-9469710-B2 Polymers functionalized with nitrile compounds containing a protected amino group BRIDGESTONE CORPORATION (JP) 2016-10-18 US disclosed
US-20150148489-A1 POLYMERS FUNCTIONALIZED WITH NITRILE COMPOUNDS CONTAINING A PROTECTED AMINO GROUP BRIDGESTONE CORPORATION (JP) 2015-05-28 US disclosed
US-8735494-B2 Polymers functionalized with nitrile compounds containing a protected amino group BRIDGESTONE CORPORATION (JP) 2014-05-27 US disclosed
US-20130085227-A1 POLYMERS FUNCTIONALIZED WITH NITRILE COMPOUNDS CONTAINING A PROTECTED AMINO GROUP BRIDGESTONE CORPORATION (JP) 2013-04-04 US disclosed
US-8344066-B2 Polymers functionalized with nitrile compounds containing a protected amino group BRIDGESTONE CORPORATION (JP) 2013-01-01 US disclosed
US-20120296041-A1 POLYMERS FUNCTIONALIZED WITH NITRILE COMPOUNDS CONTAINING A PROTECTED AMINO GROUP BRIDGESTONE CORPORATION (JP) 2012-11-22 US disclosed
US-20120059112-A1 POLYMERS FUNCTIONALIZED WITH NITRILE COMPOUNDS COMTAINING A PROTECTED AMINO GROUP BRIDGESTONE CORPORATION (JP) 2012-03-08 US disclosed
EP-2382240-A2 POLYMERS FUNCTIONALIZED WITH NITRILE COMPOUNDS CONTAINING A PROTECTED AMINO GROUP Bridgestone Corporation (JP) 2011-11-02 EP disclosed
WO-2011091346-A2 POLYMERS FUNCTIONALIZED WITH NITRILE COMPOUNDS CONTAINING A PROTECTED AMINO GROUP BRIDGESTONE CORPORATION (JP) 2011-07-28 WO disclosed
WO-2010085622-A9 POLYMERS FUNCTIONALIZED WITH NITRILE COMPOUNDS CONTAINING A PROTECTED AMINO GROUP BRIDGESTONE CORPORATION (JP) 2010-12-23 WO disclosed
WO-2010085622-A2 POLYMERS FUNCTIONALIZED WITH NITRILE COMPOUNDS CONTAINING A PROTECTED AMINO GROUP BRIDGESTONE CORPORATION (JP) 2010-07-29 WO disclosed