Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 17/20 | 0.66 |
| ▸ | BCL2L1 | Q07817 | 13/20 | 0.66 |
| ▸ | BCL2L2 | Q92843 | 2/20 | 0.47 |
| ▸ | MDM4 | O15151 | 1/20 | 0.43 |
| ▸ | BCL2L11 | O43521 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | BID | P55957 | 1/20 | 0.43 |
| ▸ | BAX | Q07812 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | ASPH | Q12797 | 1/20 | 0.43 |
| ▸ | BECN1 | Q14457 | 1/20 | 0.43 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.43 |
| ▸ | BAD | Q92934 | 1/20 | 0.43 |
| ▸ | BBC3 | Q9BXH1 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1497188 | 0.92 | BCL2 (0.77) | BCL2BCL2L1BCL2L2 | |
| SCHEMBL1497190 | 0.88 | BCL2 (0.65) | BCL2BCL2L1BCL2L2MDM4BCL2L11 | |
| SCHEMBL9951816 | 0.87 | BCL2 (0.85) | BCL2BCL2L1BCL2L2MDM4BCL2L11 | |
| SCHEMBL9951825 | 0.87 | BCL2 (0.85) | BCL2BCL2L1BCL2L2MDM4BCL2L11 | |
| SCHEMBL1497172 | 0.87 | BCL2 (0.77) | BCL2BCL2L1BCL2L2 | |
| SCHEMBL1497218 | 0.84 | BCL2 (0.77) | BCL2BCL2L1BCL2L2 | |
| SCHEMBL15958393 | 0.80 | BCL2 (0.89) | BCL2BCL2L1BCL2L2MDM4BCL2L11 | |
| SCHEMBL1497185 | 0.80 | BCL2 (0.76) | BCL2BCL2L1BCL2L2 | |
| SCHEMBL1497066 | 0.79 | BCL2 (0.70) | BCL2BCL2L1BCL2L2 | |
| SCHEMBL9951660 | 0.79 | BCL2 (1.00) | BCL2BCL2L1BCL2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2475661-A1 | SULFONAMIDES AS INHIBITORS OF BCL-2 FAMILY PROTEINS FOR THE TREATMENT OF CANCER | Novartis AG (CH) | 2012-07-18 | — | — | EP | disclosed |
| WO-2011029842-A1 | SULFONAMIDES AS INHIBITORS OF BCL-2 FAMILY PROTEINS FOR THE TREATMENT OF CANCER | NOVARTIS AG (CH) | 2011-03-17 | — | — | WO | disclosed |