Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 8/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14972704 | 1.00 | KMT2A (0.37) | KMT2AMEN1PIM1PIM3PIM2 | |
| SCHEMBL11899314 | 1.00 | KMT2A (0.37) | KMT2AMEN1PIM1PIM3PIM2 | |
| SCHEMBL11899315 | 1.00 | KMT2A (0.37) | KMT2AMEN1PIM1PIM3PIM2 | |
| SCHEMBL2276354 | 0.91 | PIM1 (0.37) | KMT2AMEN1PIM1PIM3PIM2 | |
| SCHEMBL2276357 | 0.91 | PIM1 (0.37) | KMT2AMEN1PIM1PIM3PIM2 | |
| SCHEMBL4433871 | 0.90 | MEN1 (0.41) | KMT2AMEN1CHRM4MAPTALDH1A1 | |
| SCHEMBL4132725 | 0.88 | DRD2 (0.37) | KMT2APIM1PIM3PIM2MAPT | |
| SCHEMBL11912162 | 0.88 | DRD2 (0.37) | KMT2APIM1PIM3PIM2MAPT | |
| SCHEMBL1710224 | 0.87 | MAPT (0.42) | KMT2AMEN1PIM1PIM3PIM2 | |
| SCHEMBL1710226 | 0.87 | MAPT (0.42) | KMT2AMEN1PIM1PIM3PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2596790-A1 | Pim kinase inhibitors and methods of their use | Novartis AG (CH) | 2013-05-29 | — | — | EP | disclosed |