Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A12 | P48065 | 3/20 | 0.54 |
| ▸ | SLC6A11 | P48066 | 3/20 | 0.54 |
| ▸ | SLC6A13 | Q9NSD5 | 3/20 | 0.54 |
| ▸ | GABRR1 | P24046 | 5/20 | 0.42 |
| ▸ | GABRR2 | P28476 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.32 |
| ▸ | ABAT | P80404 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21749874 | 0.86 | — | — | |
| SCHEMBL20494566 | 0.86 | — | — | |
| SCHEMBL10063860 | 0.86 | — | — | |
| SCHEMBL12284195 | 0.86 | — | — | |
| SCHEMBL13336655 | 0.86 | — | — | |
| SCHEMBL5775209 | 0.86 | — | — | |
| Hydrochloric Acid SCHEMBL1669384 | 0.83 | — | — | |
| Hydrochloric Acid SCHEMBL20168701 | 0.83 | — | — | |
| Hydrochloric Acid SCHEMBL20168285 | 0.83 | — | — | |
| SCHEMBL332930 | 0.83 | SLC6A12 (0.38) | SLC6A12SLC6A11SLC6A13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066176-B1 | IMPROVEMENTS IN AND RELATING TO PLANT PROTECTION | PLANT BIOSCIENCE LTD (GB) | 2013-05-29 | — | — | EP | claimed |