Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 17/20 | 0.42 |
| ▸ | AXL | P30530 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 10/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | GCK | P35557 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | TEK | Q02763 | 1/20 | 0.36 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.36 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.36 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14975552 | 0.93 | MET (0.44) | METAXLKDRCSF1RGCK | |
| SCHEMBL14975545 | 0.92 | MET (0.47) | METAXLKDRGCKNTRK1 | |
| SCHEMBL14975389 | 0.91 | MET (0.46) | METAXLKDRGCKNTRK1 | |
| SCHEMBL14975314 | 0.90 | KDR (0.48) | METAXLKDRNTRK1TEK | |
| SCHEMBL14975426 | 0.86 | MET (0.36) | METAXLKDRNTRK1NTRK2 | |
| SCHEMBL14975396 | 0.86 | MET (0.41) | METAXLKDRCSF1RGCK | |
| SCHEMBL14976417 | 0.86 | MET (0.44) | METAXLKDRCSF1RGCK | |
| SCHEMBL14975335 | 0.84 | AXL (0.47) | METAXLKDRNTRK1TEK | |
| SCHEMBL14975404 | 0.84 | KDR (0.43) | METKDRNTRK1TEKNTRK3 | |
| SCHEMBL14975863 | 0.83 | MET (0.42) | METAXLKDRGCKNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2782577-A2 | PYRIDONE AMIDES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES | Deciphera Pharmaceuticals, LLC. (US) | 2014-10-01 | — | — | EP | disclosed |
| WO-2013078295-A2 | PYRIDONE AMIDES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES | DECIPHERA PHARMACEUTICALS, LLC (US) | 2013-05-30 | — | — | WO | disclosed |