Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.43 |
| ▸ | BRAF | P15056 | 8/20 | 0.43 |
| ▸ | MET | P08581 | 9/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | TEK | Q02763 | 1/20 | 0.43 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.43 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.42 |
| ▸ | RIPK3 | Q9Y572 | 3/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14975314 | 0.94 | KDR (0.48) | KDRBRAFMETNTRK1TEK | |
| SCHEMBL14976417 | 0.92 | MET (0.44) | KDRBRAFMETNTRK1NTRK2 | |
| SCHEMBL14975396 | 0.92 | MET (0.41) | KDRBRAFMETNTRK1NTRK2 | |
| SCHEMBL14977826 | 0.87 | MET (0.34) | KDRMETNTRK1NTRK2 | |
| SCHEMBL14975545 | 0.86 | MET (0.47) | KDRMETNTRK1TEKNTRK3 | |
| SCHEMBL14975552 | 0.85 | MET (0.44) | KDRBRAFMETNTRK1TEK | |
| SCHEMBL14976137 | 0.84 | KDR (0.48) | KDRBRAFMETNTRK1TEK | |
| SCHEMBL14975035 | 0.84 | MET (0.42) | KDRMETNTRK1TEKNTRK3 | |
| SCHEMBL14975389 | 0.83 | MET (0.46) | KDRMETNTRK1TEKNTRK3 | |
| SCHEMBL14977853 | 0.83 | KDR (0.49) | KDRBRAFMETNTRK1TEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2782577-A2 | PYRIDONE AMIDES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES | Deciphera Pharmaceuticals, LLC. (US) | 2014-10-01 | — | — | EP | disclosed |
| WO-2013078295-A2 | PYRIDONE AMIDES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES | DECIPHERA PHARMACEUTICALS, LLC (US) | 2013-05-30 | — | — | WO | disclosed |