Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 7/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADK | P55263 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6821195 | 0.73 | GRM5 (0.56) | EGFRPDGFRBPDGFRAGRM5APP | |
| SCHEMBL4858200 | 0.69 | PDGFRB (0.46) | EGFRPDGFRBPDGFRAGRM5KCNH2 | |
| SCHEMBL6133921 | 0.69 | GRM5 (0.57) | PDGFRBPDGFRAGRM5KCNH2APP | |
| Hydrochloric Acid SCHEMBL4864461 | 0.68 | PDGFRB (0.45) | EGFRPDGFRBPDGFRAGRM5KCNH2 | |
| SCHEMBL1906166 | 0.67 | EGFR (0.52) | EGFRPDGFRBPDGFRAGRM5KCNH2 | |
| SCHEMBL15958624 | 0.67 | GRM5 (0.48) | EGFRPDGFRBPDGFRAGRM5KCNH2 | |
| SCHEMBL911440 | 0.67 | HPGD (0.40) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL29581181 | 0.67 | HPGD (0.40) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL1923029 | 0.66 | ACACB (0.52) | PDE4APDE4BPDE4CPDE4DKCNH2 | |
| SCHEMBL13865700 | 0.65 | NNMT (0.48) | PDE4APDE4BPDE4CPDE4DRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013078254-A1 | BICYCLIC HETEROARYL DERIVATIVES AS KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2013-05-30 | — | — | WO | disclosed |