Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 1/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 13/20 | 0.42 |
| ▸ | PDE2A | O00408 | 10/20 | 0.42 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | PDE6D | O43924 | 3/20 | 0.41 |
| ▸ | PDE6A | P16499 | 3/20 | 0.41 |
| ▸ | PDE6G | P18545 | 3/20 | 0.41 |
| ▸ | PDE6B | P35913 | 3/20 | 0.41 |
| ▸ | PDE6C | P51160 | 3/20 | 0.41 |
| ▸ | PDE6H | Q13956 | 3/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30142352 | 1.00 | NNMT (0.48) | NNMTPDE10APDE2APDE7AHTT | |
| SCHEMBL29581181 | 0.79 | HPGD (0.40) | NNMTPDE10APDE2APDE7AHTT | |
| SCHEMBL911440 | 0.79 | HPGD (0.40) | NNMTPDE10APDE2APDE7AHTT | |
| SCHEMBL29586509 | 0.77 | POLB (0.50) | NNMTPDE10APDE2APDE7AHTT | |
| SCHEMBL27582225 | 0.77 | POLB (0.50) | NNMTPDE10APDE2APDE7AHTT | |
| SCHEMBL10153938 | 0.77 | MAPT (0.37) | HTTKMT2ASMN1; SMN2RAB9AS1PR4 | |
| SCHEMBL172558 | 0.76 | NNMT (0.52) | NNMTPDE10APDE2APDE7AHTT | |
| SCHEMBL14975844 | 0.76 | CYP1A2 (0.39) | NNMTPDE10APDE2APDE7AHTT | |
| SCHEMBL22564747 | 0.76 | HPGD (0.38) | NNMTPDE10APDE2APDE7AHTT | |
| SCHEMBL30843221 | 0.76 | CYP1A2 (0.39) | NNMTPDE10APDE2APDE7AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021156787-A1 | HETEROCYCLIC COMPOUNDS AS DIHYDROOROTATE DEHYDROGENASE INHIBITORS | JANSSEN BIOTECH, INC. (US) | 2021-08-12 | — | — | WO | disclosed |
| WO-2020212897-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | JANSSEN BIOTECH, INC. (US) | 2020-10-22 | — | — | WO | disclosed |
| US-10513514-B2 | Piperidine compounds as PCSK9 inhibitors | SHENZHEN SALUBRIS PHARM CO LTD. (CN) | 2019-12-24 | — | — | US | disclosed |
| US-7528151-B2 | Heterocyclic urea derivatives for the treatment of pain | GLAXO GROUP LIMITED (GB) | 2009-05-05 | — | — | US | disclosed |
| US-7528151-B2 | Heterocyclic urea derivatives for the treatment of pain | GLAXO GROUP LIMITED (GB) | 2009-05-05 | — | — | US | disclosed |
| US-20070117820-A1 | Heterocyclic urea derivatives for the treatment of pain | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-05-24 | — | — | US | disclosed |
| US-20070117820-A1 | Heterocyclic urea derivatives for the treatment of pain | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070117820-A1 | Heterocyclic urea derivatives for the treatment of pain | U2SURP, UMPS, SFPQ | NNMT 1853/4885PDE10A 124/4885PDE2A 263/4885 |
| US-10513514-B2 | Piperidine compounds as PCSK9 inhibitors | PCSK9, TGFB1, PCSK7 | NNMT 2897/4885PDE10A 2033/4885PDE2A 978/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.