Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 9/20 | 0.57 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.52 |
| ▸ | ALK | Q9UM73 | 7/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.49 |
| ▸ | KIT | P10721 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14977054 | 0.92 | TBK1 (0.68) | TBK1 | |
| SCHEMBL14976945 | 0.90 | TBK1 (0.60) | TBK1TNIKKIT | |
| SCHEMBL14976819 | 0.89 | TBK1 (0.56) | TBK1TNIKALKPIK3CGKIT | |
| SCHEMBL14976939 | 0.88 | TNIK (0.59) | TBK1TNIKPIK3CG | |
| SCHEMBL14976043 | 0.86 | TBK1 (0.61) | TBK1TNIK | |
| SCHEMBL14981823 | 0.86 | TBK1 (0.51) | TBK1KIT | |
| SCHEMBL14981942 | 0.84 | TBK1 (0.70) | TBK1 | |
| SCHEMBL14976962 | 0.82 | TBK1 (0.51) | TBK1TNIKALKPIK3CGKIT | |
| SCHEMBL15555465 | 0.82 | TBK1 (0.51) | TBK1TNIKALKPIK3CG | |
| SCHEMBL14981860 | 0.81 | TBK1 (0.61) | TBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794602-B1 | 3-CYANARYL-1H-PYRAZOLO(2.3-B) PYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2017-11-29 | — | — | EP | claimed |
| US-9102675-B2 | 3-Cyanoaryl-1H-pyrrolo[2,3-B] pyridine derivatives | MERCK PATENT GMBH (DE) | 2015-08-11 | — | — | US | claimed |
| US-20140323481-A1 | 3-CYANOARYL-1H-PYRROLO[2,3-B]PYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-10-30 | — | — | US | claimed |
| EP-2794602-A1 | 3-CYANARYL-1H-PYRAZOLO(2.3-B) PYRIDINE DERIVATIVES | Merck Patent GmbH (DE) | 2014-10-29 | — | — | EP | claimed |
| WO-2013075785-A1 | 3-CYANARYL-1H-PYRAZOLO[2.3-B]PYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-05-30 | — | — | WO | claimed |
| EP-2794602-B1 | 3-CYANARYL-1H-PYRAZOLO(2.3-B) PYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2017-11-29 | — | — | EP | disclosed |
| EP-2794602-B1 | 3-CYANARYL-1H-PYRAZOLO(2.3-B) PYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2017-11-29 | — | — | EP | disclosed |
| US-9102675-B2 | 3-Cyanoaryl-1H-pyrrolo[2,3-B] pyridine derivatives | MERCK PATENT GMBH (DE) | 2015-08-11 | — | — | US | disclosed |
| US-9102675-B2 | 3-Cyanoaryl-1H-pyrrolo[2,3-B] pyridine derivatives | MERCK PATENT GMBH (DE) | 2015-08-11 | — | — | US | disclosed |
| US-9102675-B2 | 3-Cyanoaryl-1H-pyrrolo[2,3-B] pyridine derivatives | MERCK PATENT GMBH (DE) | 2015-08-11 | — | — | US | disclosed |
| US-20140323481-A1 | 3-CYANOARYL-1H-PYRROLO[2,3-B]PYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-10-30 | — | — | US | disclosed |
| US-20140323481-A1 | 3-CYANOARYL-1H-PYRROLO[2,3-B]PYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-10-30 | — | — | US | disclosed |
| US-20140323481-A1 | 3-CYANOARYL-1H-PYRROLO[2,3-B]PYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-10-30 | — | — | US | disclosed |
| EP-2794602-A1 | 3-CYANARYL-1H-PYRAZOLO(2.3-B) PYRIDINE DERIVATIVES | Merck Patent GmbH (DE) | 2014-10-29 | — | — | EP | disclosed |
| WO-2013075785-A1 | 3-CYANARYL-1H-PYRAZOLO[2.3-B]PYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-05-30 | — | — | WO | disclosed |
| WO-2013075785-A1 | 3-CYANARYL-1H-PYRAZOLO[2.3-B]PYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-05-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140323481-A1 | 3-CYANOARYL-1H-PYRROLO[2,3-B]PYRIDINE DERIVATIVES | TBK1, NFKBIA, IKBKG | TBK1 1/4885TNIK 77/4885ALK 1263/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.