Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.41 |
| ▸ | RAB9A | P51151 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2761711 | 0.79 | MEN1 (0.32) | NPC1RAB9AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL14976505 | 0.79 | NPC1 (0.38) | NPC1RAB9AMAPTPKMSMN1; SMN2 | |
| SCHEMBL9957877 | 0.78 | KDM4E (0.46) | NPC1RAB9AMAPTPKMSMN1; SMN2 | |
| SCHEMBL4808960 | 0.78 | TRIM24 (0.36) | MAPTSMN1; SMN2KDM4ECYP1A2MEN1 | |
| SCHEMBL5100088 | 0.78 | MKNK1 (0.39) | MEN1KMT2ATDP1DHODH | |
| SCHEMBL322239 | 0.77 | MEN1 (0.35) | NPC1RAB9AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL8855149 | 0.77 | MEN1 (0.35) | NPC1RAB9AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL15637499 | 0.77 | NPC1 (0.39) | NPC1RAB9AMAPTPKMSMN1; SMN2 | |
| SCHEMBL28600943 | 0.75 | PTGS2 (0.45) | MAPTSMN1; SMN2MEN1KMT2ATDP1 | |
| SCHEMBL713926 | 0.75 | KDM4E (0.50) | NPC1RAB9AMAPTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2814321-A2 | NEMATICIDAL CIS (HETERO)ARYLCYCLOPROPYLCARBOXAMIDE DERIVATIVES | Syngenta Participations AG (CH) | 2014-12-24 | — | — | EP | disclosed |
| EP-2782565-A1 | USE OF ARYL AND HETARYL CARBOXAMIDES AS ENDOPARASITICIDES | Bayer Intellectual Property GmbH (DE) | 2014-10-01 | — | — | EP | disclosed |
| WO-2013120940-A2 | NOVEL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2013-08-22 | — | — | WO | disclosed |
| WO-2013076230-A1 | USE OF ARYL AND HETARYL CARBOXAMIDES AS ENDOPARASITICIDES | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-05-30 | — | — | WO | disclosed |