Phloroglucinol

Phloroglucinol

SCHEMBL14977271

Nc1nc(N)nc(N)n1.Oc1cc(O)cc(O)c1

nearest known ligand 0.53

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8

The experimentally established mechanism targets of Phloroglucinol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BACE1 P56817 1/20 0.53
NPC1 O15118 4/20 0.48
SMN1; SMN2 Q16637 1/20 0.41
LCK P06239 1/20 0.38
LMNA P02545 2/20 0.38
CYP19A1 P11511 1/20 0.37
USP7 Q93009 1/20 0.37
ACHE P22303 1/20 0.36
POLB P06746 1/20 0.36
ADORA3 P0DMS8 1/20 0.36
ADORA2A P29274 1/20 0.36
ADORA2B P29275 1/20 0.36
ADORA1 P30542 1/20 0.36
HSP90AA1 P07900 1/20 0.35
CA12 O43570 2/20 0.35
CA2 P00918 2/20 0.35
CA9 Q16790 2/20 0.35
CA14 Q9ULX7 2/20 0.35
ALDH1A1 P00352 1/20 0.35
CYP3A4 P08684 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Resorcinol SCHEMBL10407655 0.77 CA12 (0.55) NPC1SMN1; SMN2LCKLMNAADORA2A
Phloroglucinol SCHEMBL26136276 0.73 BACE1 (0.80) BACE1NPC1SMN1; SMN2LCKLMNA
Hydroxyamine SCHEMBL8577072 0.73 LMNA (0.47) NPC1SMN1; SMN2LMNAPOLBADORA3
Hydrogen Peroxide SCHEMBL6095945 0.73 CYP1A2 (0.50) NPC1SMN1; SMN2LMNAPOLBADORA3
SCHEMBL95816 0.73
SCHEMBL8625502 0.73
Phenol SCHEMBL10783593 0.73 TDP1 (0.61) NPC1SMN1; SMN2LMNAPOLBADORA3
Phenol SCHEMBL277221 0.73 TDP1 (0.61) NPC1SMN1; SMN2LMNAPOLBADORA3
SCHEMBL9583239 0.73 CASP1 (0.50) NPC1SMN1; SMN2LMNAPOLBADORA3
SCHEMBL175612 0.73 CASP1 (0.50) NPC1SMN1; SMN2LMNAPOLBADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10174275-B2 Thermally opening stable core/shell microcapsules FOLLMANN GMBH & CO. KG (DE) 2019-01-08 US claimed
EP-2732803-B1 Thermally opening stable core/shell micro capsules FOLLMANN GMBH & CO KG (DE) 2018-04-25 EP claimed
US-20160222328-A1 THERMALLY OPENING STABLE CORE/SHELL MICROCAPSULES FOLLMANN GMBH & CO. KG (DE) 2016-08-04 US claimed
US-9056948-B2 Microcapsules and production thereof FOLLMANN & CO. GESELLSCHAFT FUER CHEMIE-WERKSTOFFE UND VERFAHRENSTECHNIK MBH & CO. KG (DE) 2015-06-16 US disclosed
US-20130137626-A1 MICROCAPSULES AND PRODUCTION THEREOF FOLLMANN & CO. GESELLSCHAFT FÜR CHEMIE-WERKSTOFFE UND VERFAHRENSTECHNIK MBH & CO. KG (DE) 2013-05-30 US disclosed